Ghulam Zahara Jahangir1*, Sana Hussain1, Sadia Manzoor1,
Sobia Shahzad2, Farah Naz3
1Centre for Applied Molecular Biology (CAMB), University of
the Punjab, Lahore, Pakistan
2Department of Botany, Islamia University of Bahawalpur,
Bahawalnagar campus, Pakistan
3National Centre of Excellence in Molecular Biology (CEMB),
University of the Punjab, Lahore, Pakistan
*For Correspondence
zahra.camb@pu.edu.pk
Dengue hemorrhagic fever (DHF)
kills estimated 390 million people yearly throughout the world, according to
the WHO in 2019. The Aedes aegypti mosquito, which carries the dengue virus, is
the source of this illness. Thrombocytopenia and dehydration are two clinical
signs of this illness to be concerned about. There are currently only two
treatment approaches: fluid replacement and symptomatic therapy. Consequently,
a therapeutic that can get around this restriction is needed. The thrombocyte
count rises because the papain in Carica papaya L. can stimulate the release of
thrombocytic cytokines including IL-6 and thrombopoietin. Megakaryocyte and
thrombocyte production can both rise with the expression of ALOX 12, which
papain can do. Using the aqueous
two-phase system and the TPP (Three Phase Partitioning) system for extraction
process, papain, extracted from Carica papaya L. Papain may be effective in
treating dengue fever and restoring normal platelet counts. Further in-depth
studies can suggest the dosage and potential adverse effects of papain drug for
treating dengue fever.
Keywords
Dengue Fever, Anti-dengue, Papain, Carica Papaya, Cytokines, Protein Purification
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