Ghulam Zahara Jahangir1*, Rida Farooq1, Saima Younas1,
Uroosa Tabarak1, Muhammad Zafar Saleem1, Aisha Younas2, Maria Rafique2
1Centre for Applied Molecular Biology (CAMB), University of
the Punjab, Lahore, Pakistan
2Lahore College for Women University (LCWU), Lahore,
Pakistan
*For Correspondence
zahra.camb@pu.edu.pk
The papaya, or Carica papaya, is
a popular tropical fruit that has been gaining attention for its purported
health advantages. Flavonoids are among the most important bioactive components
in papaya. These are a large and varied class of plant secondary metabolites
with potential medicinal utility. The presented study has been conducted to
explore the antiviral effects of the flavonoids found in Carica papaya.
Quercetin, kaempferol, and their glycosides are some of the flavonoids found in
abundance in papaya. Antioxidant, anti-inflammatory, and antibacterial
characteristics have been documented as most promising pharmacological benefits
of these flavonoids. Additionally, flavonoids from Carica papaya were studied
for their potential antiviral properties against several viruses. Papaya
flavonoids have been shown to have antiviral properties in vitro and in vivo
tests, and they may be able to inhibit the viruses spread including HIV, dengue
virus and HSV. These antiviral actions are the result of processes that block
the entrance, replication, and protein production of the invading virus. The
antiviral effect of papaya flavonoids is due, in part, to their ability to
boost the body's immunological response to viral infections; as their
immunomodulatory characteristics. These results point to Carica papaya
flavonoids as a possible natural antiviral agent. Conclusively, Carica papaya's
flavonoids have powerful antiviral actions against many different viruses. In
deep, studies can effectively find best dose and formulation of papaya
flavonoids, as well as assess their safety and effectiveness for therapeutic
use. There is hope for the creation of cutting-edge therapeutic treatments
against viral infections by drawing on Carica papaya as a source of natural
antiviral chemicals.
Keywords
Carica Papaya, Antiviral Effects, Flavonoids, Anti-inflammatory, Fruits, SARS COV-2
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