Haseeba Shahzad1*, Saba Saeed2, Hajira Kalsoom1, Fizza Mubashir1, Zulqurnain Khan3*, Khunsa Tariq4, Iqra Azhar5, Ayesha Liaqat6, Faiza Farooq7, Huma Butt8
1School of Biochemistry and Biotechnology, University of the
Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
2Institute of Biochemistry and Biotechnology, The University of
Veterinary and Animal Sciences, Lahore, Pakistan
3Institute of Plant Breeding and Biotechnology (IPBB), MNS
University of Agriculture, Multan 66000, Pakistan
4Institute of Biochemistry and Molecular Biology, Heinrich Heine
University Düsseldorf, Germany
5Department of Biochemistry, Faculty of Biological sciences
Quaid-i-Azam University, Islamabad 45320, Pakistan
6School of Biological Sciences, University of the Punjab,
Quaid-i-Azam Campus, Lahore 54590, Pakistan
7College of Pharmacy, University of Manitoba, Canada
8Department of Pharmaceutics, The Islamia University of
Bahawalpur, Pakistan
*For Correspondence
haseebashahzad388@gmail.com
zulqurnain.khan@mnsuam.edu.pk
Messenger RNA (mRNA) is in the
spotlight as a striking tool for the intervention of various human disorders
chiefly malignant tumors, now a days. Thanks to the excellent clinical
consequences of mRNA vaccines. Recent propitious preclinical and clinical outcomes
that typify the headway in mRNA and nanoformulation-based delivery scaffolds
have illuminated the efficacious aptitude of mRNA in cancer immunotherapy. The
mRNA can be used for cancer immunotherapy in the form of many therapeutic
techniques like adoptive T-cell therapy, therapeutic antibodies, cancer
vaccines and immunomodulatory proteins. This chapter highlights the
comprehensive overview of the evolving role of mRNA technology against cancer,
the underlying mode of action of various types of emerging mRNA-based cancer
vaccines as well as immunomodulatory proteins, current status and anticipation
of mRNA-based therapeutics inclusive of various delivery strategies as well as
has opened new avenues to overcome the deficiencies.
Keywords
mRNA Technology, Cancer Immuno-therapy, Biochemical, Clinical Aspects, Recent Study
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