Diego Tomassone1
1Holos Medica Clinical and
Research, 38068 Rovereto, Italy
*For Correspondence
diego.tomassone81@gmail.com
The COVID-19 pandemic has profoundly reshaped oncologic practice,
introducing a range of clinical, biological, and ethical challenges. In
particular, the interaction between SARS-CoV-2 and tumor biology has revealed
complex mechanisms involving gene regulation, systemic inflammation, immune
dynamics, and therapeutic vulnerability. Simultaneously, COVID-19 vaccination
has introduced immunological and molecular variables that warrant thorough
investigation, especially in cancer patients undergoing immunotherapy.
This chapter presents an interdisciplinary analysis of the biological
interplay between cancer and COVID-19, with a specific focus on the
implications of vaccination within the framework of precision oncology. It
explores shared molecular pathways, alterations in the tumor immune
microenvironment (TiME), therapeutic implications, and translational prospects.
By integrating molecular oncology, immunology, virology, bioethics, and
computational science, the chapter offers a comprehensive and up-to-date perspective.
Through a critical review of the literature and the exploration of
predictive models, this work aims to contribute to the development of
personalized, resilient, and evidence-based therapeutic strategies essential
for navigating the evolving landscape of oncologic care in pandemic and
post-pandemic settings.
Keywords
Cancer and COVID-19, Precision Oncology, COVID-19 Vaccination, Tumor Immune Microenvironment (TiME), Immunotherapy, Virus–tumor Interactions, Immune Response, Molecular Vulnerability, Multidisciplinary Approach, Translational Research
Download PDF